(08.10.2015, 08:25)Pygar schrieb: Jetzt hast du mich auf das Thema angefixt 
Mich auch! Offensichtlich ist es wissenschaftlich klar nachgewiesen, dass der Anteil der "Verkalkung" der Zirbeldrüse korreliert mit verringertem REM-Anteil, verringerter Gesamtschlafzeit und reduzierter Schlafeffizienz: Sleep Medicine, 10, (4), 439-445 (2009). Dieser Artikel kostet leider 35$, hier ist der Abstract:
Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patients Original Research Article:
Abstract
Objective
Melatonin plays a key role in the proper functioning of the circadian timing system (CTS), and exogenous melatonin has been shown to be beneficial in cases of CTS and sleep disturbances. Nevertheless, the concept of “melatonin deficit” has yet to be defined. The aim of our study was, therefore, to determine the relationship between the degree of pineal calcification (DOC) and a range of sleep parameters measured objectively using polysomnography (PSG).
Methods
A total of 31 outpatients (17 women, 14 men, mean age 45.9 years; SD 14.4) with primary insomnia were included in our study. Following an adaptation night, a PSG recording night was performed in the sleep laboratory. Urine samples were collected at predefined intervals over a 32-h period that included both PSG nights. The measurement of 6-sulphatoxymelatonin (aMT6s) levels was determined using ELISA. DOC and volume of calcified pineal tissue (CPT) and uncalcified pineal tissue (UPT) were estimated by means of cranial computed tomography.
Results
UPT was positively associated with 24-h aMT6s excretion (r = 0.569; P = 0.002), but CPT was not. After controlling for age, aMT6s parameters, CPT, and UPT did not correlate with any of the PSG parameters evaluated. In contrast, DOC was negatively associated with REM sleep percentage (r = −0.567, P = 0.001), total sleep time (r = −0.463, P = 0.010), and sleep efficiency (r = −0.422, P = 0.020).
Conclusion
DOC appears to be a superior indicator of melatonin deficit compared to the absolute amount of melatonin in the circulation. High DOC values indicate changes predominantly in the PSG parameters governed by the circadian timing system. DOC may thus serve as a marker of CTS instability.
(08.10.2015, 09:30)clearseven schrieb: Über DMT und Pinolin schweigt sie sich aus, auch das Wikipedia berichtet nichts über psychoaktive Stoffe.
Stimmt leider fast! Hier eine frühe Ausnahme:
Article
The biosynthesis of 5-methoxy-N,N-dimethyltryptamine
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Lewis R. Mandel
•
Robert W. Walker
Merck Sharp & Dohme Research Laboratories Rahway, New Jersey 07065, USA
Life Sciences (Impact Factor: 2.7). 11/1974; 15(8):1457-63. DOI: 10.1016/0024-3205(74)90120-9
Source: PubMed
ABSTRACT
Indoleamine-N-methyltransferase from rabbit and human lung catalyzes the N-methylation of 5-methoxytryptamine to form 5-methoxy-N-methyltryptamine, which in turn, is converted to 5-methoxy-N,N-dimethyltryptamine. S-Adenosylmethionine is the methyl donor for these reactions. There was no evidence for the 0-methylation of bufotenin by either S-adenosylmethionine or 5-methyltetrahydrofolic acid using enzymes from rabbit lung, rat brain and liver, or chick heart.
Wikipedia kennt DMT und Pinoline allerdings sehr wohl:
https://de.wikipedia.org/wiki/Dimethyltryptamin
https://en.wikipedia.org/wiki/Pinoline
Gruß
Wizard